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“Lattice Boltzmann simulations of Bending Effects of Microvilli of Leukocyte on Rolling Adhesion”

发布者:Qi Dewei发布时间:2018-06-22浏览量:

湖南大学“天马材料研究论坛”第129

  目:Lattice Boltzmann simulations of Bending Effects of Microvilli of Leukocyte on Rolling Adhesion(点阵玻尔兹曼模拟白细胞微绒毛弯曲对滚动粘附的影响)

报告人: Qi Dewei 教授 (美国西密歇根大学教授)

  点:工程实验大楼244或240多媒体报告厅

  间:2018年6月28日(周四)上午9:30-11:00

主持人: 教授

邀请人: 材料科学与工程学院

承办人: 材料学院“天马材料研究论坛”日常工作小组



报告人简介:

Dewei Qi ,  professor, Chemical and Paper Engineering Department, Western Michigan University, USA.

Education: Ph.D. Physics, University of Waterloo, 1992.

Worked  as a visiting professor at AIR FORCE BASE, WRIGHT PATTERSON, DAYTON, OH; NATIONAL INSTITUTE OF AEROSPACE; INSTITUTE FOR COMPUTER APPLICATIONS IN SCIENCE & ENGINEERING, NASA, Langley NASA

Research Areas:  lattice-Boltzmann simulations of multi flexible bodies in fluids;  fiber physics; papermaking;  recycling; blood  and bio-fluids.


Abstract

It has been widely acknowledged that further understanding about the cell adhesion (e.g., leukocyte rolling adhesion) can help us gain more knowledge about the causes of relevant   diseases and design more effective treatments and diagnoses. Although recent simulation studies considered the deformability of the leukocytes, most of them, however, did not consider the bending deformation of microvilli. In this paper, an advanced leukocyte model based on an immersed boundary lattice-Boltzmann lattice-spring model (LLM) and an adhesive dynamics (AD) is presented in details. The flexural stiffness of microvilli is introduced into the model for simulations of leukocyte rolling adhesion. This innovative model is applied to investigate the influences of bending deformation of microvilli on the process of leukocyte rolling adhesion and the underlying mechanism at different shear rates. It is demonstrated that the bending deformation of microvilli can be influenced by the flexural stiffness of microvilli and shear rates, resulting in the different rolling velocity of leukocytes, number of receptor-ligand bonds, and bond forces. The findings clearly indicate that the bending of microvilli plays a crucial role in the dynamics of leukocyte adhesion.

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